Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

Read More..

Exhausted Egyptians count cost of political turmoil

ZAGAZIG, Egypt (Reuters) - These days, craftsmen, shopkeepers and other inhabitants of the Egyptian Delta town of Zagazig are often too busy making ends meet to ponder why life seems to be getting harder every day.

But when, exhausted, they finally come home and sit down to their evening meal, conversations inevitably turn to growing hardship and the frightening prospect of cuts in food subsidies as the economy slides further into crisis.

With their patience already stretched after years of upheaval, Egyptians - from the capital Cairo to smaller towns like Zagazig - appear to be nearing the point where discontent could explode into a new wave of unrest.

"There is no security. There is nothing," said Soheir Abdel Moneim, a retired school teacher, as she hurried through an open-air market in Zagazig in search of vegetables she could afford.

"The pound is falling. Everything is more expensive. Is there anything that has not become more expensive?" she asked with a shrug, as traders on bicycles loaded with their wares dodged through the chaos of the market.

Nearby, a torn poster of President Mohamed Mursi beams from the wall of a crumbling brick house, with the words "Liars! Liars!" scrawled over his face.

The mood of growing nervousness is bad news for Mursi, who faces a parliamentary election in coming months, and a new round of political feuding that could pitch Egypt back into civil strife.

Egypt's economy, once strong and popular among investors, has been in tatters since the revolt of 2011 that ousted Hosni Mubarak and shook the country to its foundations.

Disagreements over a new national constitution late last year triggered violent protests, dealing another blow to the economy and eroding trust in Mursi's government.

A country where cuts in food subsidies have caused riots in the past now faces the risk of further upheaval as Mursi prepares to impose austerity measures in order to obtain a desperately needed $4.8 billion loan from the International Monetary Fund.

In Zagazig, people worry about the future.

Farouk Sarhan, the 74-year-old manager of a shop selling women's clothes, said sales were already down by almost 50 percent from just a few weeks ago.

"No one is selling or buying. I had more activity last year," he said, stubbing out a cigarette with a deep sigh in his tiny store lined with mannequins of veiled women.

"Customers are not buying as much as before because of the economic situation."

The price of fresh food often goes up in winter but shoppers in the Zagazig market said recent increases had been steep, with tomatoes and cauliflower about 50 percent dearer than at the start of the year.

WHAT NEXT?

Egypt has been on the ropes since investors and tourists fled after the revolt, when people rose up to demand their freedom and also an end to economic policies they said simply lined the pockets of the rich.

On the economic front, the picture remains grim, although Qatar's decision to lend Egypt another $2 billion has offered some respite.

Foreign reserves are dwindling and the pound has been hitting new lows daily. Food and raw materials from abroad have become more expensive, hurting businesses and families in a desert nation which relies on imports to feed itself.

As in other parts of Egypt, people in Zagazig see complex economic trends in terms of the daily hardships they must endure, and it is Mursi's government and his Muslim Brotherhood allies who get the blame.

"Mursi doesn't feel our grievances," said Emad, a man in his late 30s who sells traditional Egyptian clothes by the side of a dusty street. He said he had been forced to raise prices to cover rising costs, upsetting his customers.

Pointing to one of the black embroidered gowns, Emad said: "We used to sell this for 35 pounds ($5.40). Now it's 45 pounds. We didn't raise the prices. Traders did.

"Very few people are buying. I used to sell 50 pieces a day, and now I sell 15 or 20. Today I still haven't sold anything."

Reliable opinion polls are unavailable in Egypt and it is hard to gauge how widespread people's views are. But in Zagazig, most of those interviewed by Reuters echoed Emad's feelings.

Economists worry that continued turmoil could prompt people and businesses to convert their savings into dollars en masse - a risky process known as dollarisation which has caused trouble in many emerging market crises before.

But in Zagazig, people laughed at the idea, saying only the rich could afford to buy foreign currency. "Dollars?" asked Nabil, a local trader, as others burst into laughter. "Give me some dollars! Of course we don't have any!"

SUPPORT FOR MURSI

But some were prepared to give Mursi a chance.

In the nearby village of al-Adwa, where the future president grew up in the family of a local farmer, brick walls and fences were plastered with posters of Mursi.

A crowd of farmers standing by the side of a dirt track cutting through the village shook their fists and shouted "Mursi! Mursi!" when asked about their political views.

But even in Adwa, where Mursi appeared to enjoy rock-solid support, locals said sudden increase in taxes or abrupt cuts to fuel or food subsidies would cost him dearly.

"If that happens that would be the worst thing. What am I going to do as a farmer?" said Said Youssef, his hands black from working the land. "Where are we going to get the money?"

Another man, Aly Saber, 65, said fertilizer prices had gone up by 50 Egyptian pounds in the past year alone, making his business less profitable.

"Things are tough here in the rural areas," he said as others nodded in agreement. "Everything is becoming more expensive."

Mohamed Gamal, the 42-year-old owner of a tiny shop selling kitchen appliances, said business was so bad that he would sometimes go for days without a single customer.

"I import goods all the time. Prices have gone up by 10-40 percent since the revolution. It's gone up even more in recent weeks," said Gamal, who, Like Mursi, grew up in Adwa.

He said his neighbors were suspicious about why he had to keep raising his prices.

"People just don't believe me," he said, hunched over his desk, cigarette smoke swirling above stacks of unsold trays, cups and ironing boards. "They are not convinced why things are getting more expensive. I buy them, and they stack up."

($1 = 6.4809 Egyptian pounds)

(Writing by Maria Golovnina; Editing by Giles Elgood)

Read More..

European businesses slow to go online: study

BRUSSELS (Reuters) – European businesses are not doing enough to use the internet to grow their customer base and promote products, Belgian database and marketing firm Email-Brokers said after studying 13 million websites.

Belgium, Germany and the Netherlands have the highest proportion of companies online but even in these countries 40 percent of business have no internet presence, it found.

The European Commission has estimated that companies which exploit the full potential of the internet create, on average, more than twice as many jobs.

“It is one of the ways to create employment and economic growth and it is not Star Trek, it exists today,” Email-Brokers head William Vande Wiele said.

Britain and Liechtenstein were the most advanced in terms of e-commerce – defined as being able to process orders and payments, with 16 percent and 17 percent, respectively, of business sites offering it, compared with 6 percent in Belgium and 9 percent in Austria, Germany and the Netherlands.

Vande Wiele said many corporate websites were badly designed, and did not provide basics such as adequate contact information or company details.

In Belgium, 91 percent of all corporate websites did not meet such basic standards, compared with about 20 percent in Luxembourg and France, the study concluded.

“Sites which do not comply with such minimum standards do not inspire confidence and before buying something online a user will need a minimum level of confidence,” Vande Wiele said.

Many websites are not kept up to date, the study also found, with more than 80 percent of business sites in Belgium, Greece, Italy and Spain not updated for more than a year.

(Reporting by Robert-Jan Bartunek; Editing by Dan Lalor)

Internet News Headlines – Yahoo! News

Title Post: European businesses slow to go online: study
Url Post: http://www.news.fluser.com/european-businesses-slow-to-go-online-study/
Link To Post : European businesses slow to go online: study
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment

Read More..

Ryan Gosling: How He Weaves His Magic Spell

01/09/2013 at 08:00 AM EST

Devoted son, quirky leading man – and everyone's favorite fantasy boyfriend.

But how does Ryan Gosling stack up in his real-life romance with actress Eva Mendes?

The "hey girl" Internet obsession, 32, "is an incredibly sweet boyfriend," a Gosling source tells PEOPLE in this week's cover story. He and Mendes, 37, "get along so well because she's not needy or smothering," says another insider. "They just work."

Mendes is hardly the only one to fall under Gosling's spell. The former Mouseketeer – who brought his mom, Donna, as his date to the Jan. 7 Gangster Squad premiere in L.A. – is "funny and charming," says the film's director, Ruben Fleischer.

"When you're with him you feel different. He has a magnetic quality – larger than life."

And yes, he knows how to work his quirks – everything from self-designed tattoos to an enduring Disneyland fascination.

"Women love him because he's just kooky," says the insider. "He's definitely in touch with his childlike side."

For much more on Ryan – including photos of all his sexiest looks – pick up this week's PEOPLE, on newsstands Friday

Read More..

Report: Death rates from cancer still inching down

WASHINGTON (AP) — Death rates from cancer are continuing to inch down, researchers reported Monday.

Now the question is how to hold onto those gains, and do even better, even as the population gets older and fatter, both risks for developing cancer.

"There has been clear progress," said Dr. Otis Brawley of the American Cancer Society, which compiled the annual cancer report with government and cancer advocacy groups.

But bad diets, lack of physical activity and obesity together wield "incredible forces against this decline in mortality," Brawley said. He warned that over the next decade, that trio could surpass tobacco as the leading cause of cancer in the U.S.

Overall, deaths from cancer began slowly dropping in the 1990s, and Monday's report shows the trend holding. Among men, cancer death rates dropped by 1.8 percent a year between 2000 and 2009, and by 1.4 percent a year among women. The drops are thanks mostly to gains against some of the leading types — lung, colorectal, breast and prostate cancers — because of treatment advances and better screening.

The news isn't all good. Deaths still are rising for certain cancer types including liver, pancreatic and, among men, melanoma, the most serious kind of skin cancer.

Preventing cancer is better than treating it, but when it comes to new cases of cancer, the picture is more complicated.

Cancer incidence is dropping slightly among men, by just over half a percent a year, said the report published by the Journal of the National Cancer Institute. Prostate, lung and colorectal cancers all saw declines.

But for women, earlier drops have leveled off, the report found. That may be due in part to breast cancer. There were decreases in new breast cancer cases about a decade ago, as many women quit using hormone therapy after menopause. Since then, overall breast cancer incidence has plateaued, and rates have increased among black women.

Another problem area: Oral and anal cancers caused by HPV, the sexually transmitted human papillomavirus, are on the rise among both genders. HPV is better known for causing cervical cancer, and a protective vaccine is available. Government figures show just 32 percent of teen girls have received all three doses, fewer than in Canada, Britain and Australia. The vaccine was recommended for U.S. boys about a year ago.

Among children, overall cancer death rates are dropping by 1.8 percent a year, but incidence is continuing to increase by just over half a percent a year. Brawley said it's not clear why.

Read More..

Wall Street set to open higher after Alcoa's positive results

NEW YORK (Reuters) - Wall Street was poised to open slightly higher on Wednesday after Alcoa got the earnings season under way with better-than-expected revenue and an encouraging outlook for the year.

Alcoa Inc said it expects global demand for aluminum will continue to grow in 2013, though the company kept a cautious tone as worries lingered over a looming U.S. budget confrontation. Shares of Alcoa, the largest aluminum producer in the United States, rose 1.7 percent to $9.25 in premarket trade.

Still, investors are wary about the outcome of the fourth-quarter earnings season. Profits were expected to beat the previous quarter's lackluster results, but analyst estimates were down sharply from where they were in October. Earnings were expected to grow by 2.7 percent, according to Thomson Reuters data.

Equities have pulled back over the last two sessions from last week's rally, which was spurred by the "fiscal cliff" deal in Washington.

"With the euphoria of the fiscal cliff deal wearing off, the market is looking for the next positive theme and the hope is that earning season can fill that need," said Andre Bakhos, director of market analytics at Lek Securities in New York.

"With expectations muted, any semblance of decent numbers could provide a robust upside potential."

Among other earnings, Constellation Brands , whose labels include Robert Mondavi and Ravenswood wines, rose 4 percent to $37.50 after it reported higher profit.

But on the downside, Apollo Group Inc slid more than 10 percent after it reported lower student sign-ups for the third straight quarter and cut its operating profit forecast for 2013. Apollo's shares were indicated at $18.84.

S&P 500 futures rose 1.7 points and were above fair value, a formula that evaluates pricing by taking into account interest rates, dividends and time to expiration on the contract. Dow Jones industrial average futures added 15 points, and Nasdaq 100 futures gained 1.5 points.

Dish Network Corp late Tuesday announced a bid for Clearwire Corp that trumped Sprint Nextel Corp's $2.2 billion offer, setting the stage for a battle over the wireless service provider.

Clearwire was up 7.2 percent at $3.13, while Sprint lost 2.5 percent to $5.82.

Hard drive maker Seagate Technology rose 2.7 percent to $32.25 after it raised its second-quarter revenue forecast.

Apple Inc is working on a lower-end iPhone, the Wall Street Journal reported, citing sources. The report comes as Apple's chief executive meets with partners and government officials in China.

Goldman Sachs Group Inc and Morgan Stanley are among a group of banks expected to agree as soon as this week to a $1.5 billion settlement with U.S. regulators over botched foreclosure claims, sources told Reuters on Tuesday.

(Editing by Kenneth Barry)

Read More..

Tunisia frees man held over attack on U.S. consulate in Libya

Tunis (Reuters) - Tunisia has freed, for lack of evidence, a Tunisian man who had been suspected of involvement in an Islamist militant attack in Libya last year in which the U.S. ambassador was killed, his lawyer said on Tuesday.

Ali Harzi was one of two Tunisians named in October by the Daily Beast website as having been detained in Turkey over the violence in which Christopher Stevens, the U.S. ambassador to Libya, and three other American officials were killed.

"The judge decided to free Harzi and he is free now," lawyer Anouar Awled Ali told Reuters. "The release came in response to our request to free him for lack of evidence and after he underwent the hearing with American investigators as a witness in the case."

A Tunisian justice ministry spokesman confirmed the release of Harzi but declined to elaborate.

A month ago, Harzi refused to be interviewed by visiting U.S. FBI investigators over the September 11 assault on the U.S. consulate in the eastern Libyan city of Benghazi.

The Daily Beast reported that shortly after the attacks began, Harzi posted an update on an unspecified social media site about the fighting.

It said Harzi was on his way to Syria when he was detained in Turkey at the behest of U.S. authorities, and that he was affiliated with a militant group in North Africa.

(Reporting by Tarek Amara; Editing by Mark Heinrich)

Read More..

Conn. lawmaker apologizes over Facebook post

HARTFORD, Conn. (AP) — A Connecticut lawmaker has apologized after saying in a Facebook post that shooting victim and former Arizona U.S. Rep. Gabrielle Giffords should “stay out of my towns.”

Giffords last week visited Newtown, Conn., where a gunman killed 20 young children and six adults at an elementary school last month. The Democrat, who met with families of the victims, was critically wounded two years ago in a deadly mass shooting in Tucson, Ariz.

The Hartford Courant posted images Sunday showing Republican state Rep. DebraLee Hovey‘s Facebook comments. In one dated Friday she says, “Gabby Giffords stay out of my towns!!”

Hovey released a statement Monday saying her comments were insensitive and that she apologizes if she offended anyone.

Hovey had said in another post that the visit was political.

Social Media News Headlines – Yahoo! News

Title Post: Conn. lawmaker apologizes over Facebook post
Url Post: http://www.news.fluser.com/conn-lawmaker-apologizes-over-facebook-post/
Link To Post : Conn. lawmaker apologizes over Facebook post
Rating:
100%

based on 99998 ratings.
5 user reviews.
Author: Fluser SeoLink
Thanks for visiting the blog, If any criticism and suggestions please leave a comment

Read More..

Jessica Alba: Cash Warren and I Are 'Kindred Spirits'

Courtesy InStyle

Love may not have struck at first sight for Jessica Alba and Cash Warren, but the pair’s instant connection was enough to last a lifetime.

“I just knew when I met him that I was going to know him forever. It was weird; He instantly felt like family,” the actress, 31, says in InStyle‘s February issue.

“I’d never felt like that with anyone. We got each other. We’re kindred spirits.”

Following their “very, very, very short” run as friends, the couple began dating and eventually tied the knot in 2008 before welcoming daughters Honor Marie, 4½, and Haven Garner, 16 months.

The spark between the sweethearts is still going strong, although Alba admits their idea of romance has certainly undergone changes over the years.

“On a weekend Cash might say, ‘Go get your nails done with a girlfriend. Haven is down for a nap and Honor and I will play. I know you work hard. You deserve some time for yourself,’” she says.

“That, to me, is romantic. He’s saying, ‘You matter,’ and that I’m more than just the mother of the kids or the wife who goes out to events with him.”

Blending their ethnically diverse backgrounds under one roof, the parents have made their home a true family affair, highlighting — and celebrating! — their ancestral roots.

“When Cash and I moved into our family house, we collected hundreds of pictures of our aunties, great aunties, moms and dads, grandmas and grandpas, and sisters and brothers,” Alba shares. “Then we mounted them in the foyer of our home, covering the wall from top to bottom. Our daughters are continually reminded of where they come from.”

Life’s not all play for the mom-of-two; In addition to her acting career and taking care of her girls, the multi-talented mama is also the mastermind behind The Honest Company, her eco-friendly line of home goods she cofounded with Christopher Gavigan.

With such a full plate to balance, the actress has been known to take on a bit more than she can handle.

“Sometimes I can take multitasking to a level of insanity,” Alba explains. “Then all of a sudden the bath is too high and I’ve forgotten to give my daughter the thing she needs for school.”

Fortunately, her family of four has taught Alba how to worry less about the mess-making and more about making the memories.

“Before I had kids, I was very responsible and serious. I used to be all about controlling my environment; Everything had to be just so,” she says. ”Now my idea of perfection is different. You can label bins and have a place for stuff, but when the kids go into the playroom, you’re not going to say, ‘We can’t paint because how are we going to clean it up?’”

– Anya Leon

Read More..

Stock futures flat as earnings season begins

NEW YORK (Reuters) - Stock index futures were little changed in low volume on Tuesday before the unofficial start of the earnings season, which is expected to show sluggish corporate growth.

Profits in the fourth quarter were expected to top the previous quarter's lackluster results, but analysts' current estimates are down sharply from where they were in October. Quarterly earnings are expected to grow by 2.8 percent, according to Thomson Reuters data.

German data showed industrial orders fell more than forecast in November due to a sharp drop in demand from abroad, reinforcing concerns that Europe's largest economy may have contracted in the fourth quarter of 2012.

"I'm surprised futures are holding up, given the relative disappointment that German data showed, but I think all eyes are on the beginning of earnings season," said Kim Forrest, senior equity research analyst at Fort Pitt Capital Group in Pittsburgh.

Monsanto Co , Apollo Group and Dow component Alcoa Inc start the quarterly season.

Monsanto shares rose 3.2 percent to $99 after announcing first-quarter results and the company's outlook.

"Alcoa is not a huge bellwether," Forrest said. Investors are now focused more on companies' performance than on macroeconomic factors, so "we should be kind of flat until we get some company-oriented news," she said.

S&P 500 futures were off 0.8 point and slightly below fair value, a formula that evaluates pricing by taking into account interest rates, dividends and time to expiration on the contract. Dow Jones industrial average futures were unchanged, and Nasdaq 100 futures fell half a point.

Shares of Yum Brands Inc fell 5 percent to $64.50 in premarket trading a day after the KFC parent warned sales in China shrank more than expected in the fourth quarter.

Sears Holdings shares rose 5.5 percent to $45.27 in light premarket trading a day after the company said its chief executive will step down for family health reasons. The U.S. retailer also reported a 1.8 percent decline in quarter-to-date sales at stores open at least a year.

ConAgra Foods Inc priced a public offering of 8.1 million common shares at $29.75 per share, the foodmaker said on Monday. ConAgra closed at $30.17 during regular Monday trading.

(Reporting by Rodrigo Campos; Editing by Jeffrey Benkoe and Kenneth Barry)

Read More..